Related Experiment Video
Updated: Jul 25, 2025

Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
[Recent Research Progress on CircRNA in Hematological Malignancies--Review]
Xue Bai1, Xiao-Feng Chen1, Zhong-Yu Li1
1Department of Hematology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233003, Anhui Province, China.
Abstract:
Most hematological tumors have high-grade malignancy and low cure rate, requiring new molecular markers for detection and evaluation. Circular RNAs (circRNAs) are a class of non-coding RNAs with covalently closed-loop structures, which participate in gene transcription and translation by binding to microRNAs and proteins. In recent years, with the deepening research on circRNAs, circRNAs have been found to play an important role in hematological malignancies. In this review, the latest research progress on the function and molecular mechanism of circRNAs in hematological malignancies was systematically summarized, and it was found that circRNAs may be potential new biomarkers and therapeutic targets in hematological malignancies.
Related Concept Videos
lncRNA - Long Non-coding RNAs
Abnormal Proliferation
The Nucleolus
Regulation of Hematopoietic Stem Cells
Targeted Cancer Therapies
There are several types of targeted therapies against...
Hematopoiesis

