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Strong PD-L1 expression in granulomatous prostatitis.

Dorian Dikov1,2, Maria Koleva1, Angelina Mollova1

  • 1Department of General and Clinical Pathology, Medical University of Plovdiv, Plovdiv, Bulgaria.

The Prostate
|June 26, 2023
PubMed
Summary

Programmed cell death ligand protein (PD-L1) is strongly expressed in granulomatous prostatitis (GP), aiding diagnosis. This finding helps identify granulomatous inflammation in prostate tissue, improving diagnostic accuracy for this condition.

Keywords:
PD-L1carcinomagranulomatous prostatitislymphoepithelial lesionsprostatitis

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Area of Science:

  • Urology
  • Immunology
  • Pathology

Background:

  • Programmed cell death ligand protein (PD-L1) expression is understudied in non-tumoral and inflammatory prostate conditions.
  • Diagnosing granulomatous prostatitis (GP) can be challenging using conventional histology alone.
  • PD-L1 expression in GP has not been extensively investigated.

Purpose of the Study:

  • To investigate PD-L1 expression in various forms of granulomatous prostatitis (GP).
  • To assess the utility of PD-L1 as a diagnostic marker for GP.
  • To compare PD-L1 expression in GP with control prostate tissues.

Main Methods:

  • Studied PD-L1 expression in 17 cases of GP, including nonspecific GP, BCG-induced prostatitis, tuberculosis, and postsurgical granulomas.
  • Utilized a control group of 10 radical prostatectomies from patients with prostate adenocarcinoma (PCa) and high-grade histologic prostatitis (HG-HP).

Main Results:

  • All GP cases exhibited strong, easily visible membranous PD-L1 expression in granulomatous inflammation.
  • Control cases, including HG-HP and PCa tissues, showed no significant PD-L1 expression in inflammatory infiltrates, tumor parenchyma, or stroma.

Conclusions:

  • This study is the first to examine PD-L1 expression in granulomatous prostatitis (GP).
  • PD-L1 staining effectively identifies granulomatous inflammation in GP, suggesting its utility as a diagnostic aid.