Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin...

Area of Science:

• Dermatology
• Cosmetology
• Aesthetic Medicine

Background:

• Polyhydroxy acids and alpha-hydroxy acids are common in cosmetic skin treatments.
• Gluconolactone chemical peeling can be enhanced by combining it with oxybrasion or microneedle mesotherapy.

Purpose of the Study:

• To assess the impact of a 10% gluconolactone chemical peel combined with oxybrasion and microneedling on key skin parameters.
• The study aimed to evaluate changes in skin hydration, sebum levels, pH, and transepidermal water loss (TEWL).

Main Methods:

• Twenty-one Caucasian women underwent a series of three split-face treatments at weekly intervals.
• The right side of the face received oxybrasion, while the left side underwent micro-needle mesotherapy, with a 10% gluconolactone peel applied to the entire face.
• Skin parameters were measured before the first and third treatments, and two weeks post-treatment, with photographic documentation.

Main Results:

• Both combined treatment methods resulted in increased skin hydration.
• A decrease in sebum levels, skin pH, and TEWL was observed for both oxybrasion and microneedling combinations.
• No statistically significant differences were found between the efficacy of oxybrasion and microneedling when combined with gluconolactone peeling.

Conclusions:

• Combining gluconolactone chemical peeling with either oxybrasion or microneedle mesotherapy is an effective strategy for improving skin barrier function.
• These combined treatments successfully enhance skin hydration and help regulate sebum production, pH, and TEWL.
• The study supports the use of these combined methods for improved skin health and appearance.