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Published on: June 13, 2010
Atomic-precise Pt2Cu4 cluster-based fluorescent sensor for rapid interleukin-6 detection
Zi-Hui Shao1, Hui-Lin Mo1, Xueli Zhao1
1Henan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostic Cluster Materials, Green Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China. xuelizhao@zzu.edu.cn.
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Levonorgestrel protected Pt2Cu4 clusters were assembled with a polymer to prepare nanobeads (NBs) with intense red fluorescence. An immunofluorescence sensor based on Pt2Cu4NBs was established for the rapid and sensitive detection of interleukin-6 (IL-6) owing to its significance in inflammatory diseases, with a limit of detection of 42.66 pg mL-1. IL-6 spiked in serum was also accurately detected.
