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Atomic-precise Pt2Cu4 cluster-based fluorescent sensor for rapid interleukin-6 detection.

Zi-Hui Shao1, Hui-Lin Mo1, Xueli Zhao1

  • 1Henan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostic Cluster Materials, Green Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China. xuelizhao@zzu.edu.cn.

Analytical Methods : Advancing Methods and Applications
|June 26, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed fluorescent nanobeads using levonorgestrel-protected platinum-copper clusters. These nanobeads enable rapid and sensitive detection of interleukin-6 (IL-6), a key marker in inflammatory diseases.

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Interleukin-6 (IL-6) is a critical cytokine involved in inflammatory diseases.
  • Sensitive detection of IL-6 is crucial for early diagnosis and monitoring of inflammatory conditions.
  • Existing detection methods may lack the required speed, sensitivity, or simplicity.

Purpose of the Study:

  • To develop a novel fluorescent nanobead (NB) platform for detecting interleukin-6 (IL-6).
  • To establish an immunofluorescence sensor for rapid and sensitive IL-6 quantification.
  • To evaluate the sensor's performance in detecting IL-6 in biological samples like serum.

Main Methods:

  • Synthesis of levonorgestrel-protected platinum-copper (Pt2Cu4) clusters.
  • Assembly of Pt2Cu4 clusters with a polymer to form intensely red-fluorescent nanobeads.
  • Development of an immunofluorescence assay utilizing the Pt2Cu4 NBs for IL-6 detection.

Main Results:

  • Successfully prepared Pt2Cu4 nanobeads exhibiting strong red fluorescence.
  • Established an immunofluorescence sensor with a low limit of detection for IL-6 (42.66 pg mL-1).
  • Demonstrated accurate detection of spiked IL-6 levels in human serum samples.

Conclusions:

  • The developed Pt2Cu4 nanobead-based immunofluorescence sensor offers a promising tool for rapid and sensitive IL-6 detection.
  • This platform has potential applications in diagnosing and monitoring inflammatory diseases.
  • The study highlights the utility of functionalized metal clusters in developing advanced biosensing technologies.