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Updated: Jul 25, 2025
04:37
Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
Published on: June 6, 2025
176
Characterization of Individuals With Apparent Resistant Hypertension Using Contemporary Guidelines: Insights From
Joseph E Ebinger1, Ty J Gluckman2, Jose Magraner1
1Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (J.E.E., J.M.).
Hypertension (Dallas, Tex. : 1979)
|June 26, 2023
Summary
Apparent resistant hypertension (aRH) affects 8.5% of hypertensive patients, often with more comorbidities. Controlled aRH patients more frequently receive mineralocorticoid receptor antagonists, suggesting improved care opportunities.
Area of Science:
- Cardiology
- Hypertension Research
- Clinical Pharmacology
Background:
- Apparent resistant hypertension (aRH) is linked to increased cardiovascular risk.
- Current understanding of aRH patient characteristics and treatment patterns is limited.
- Contemporary US hypertension guidelines define aRH criteria.
Purpose of the Study:
- Evaluate the prevalence of aRH using current guidelines.
- Describe clinical characteristics of patients with aRH.
- Analyze pharmacotherapeutic patterns in aRH patients.
Main Methods:
- Classified patients from 3 healthcare systems based on contemporary hypertension guidelines.
- Described demographic and clinical features of aRH patients.
- Compared characteristics between aRH and non-aRH patients, and between controlled and uncontrolled aRH.
Main Results:
- Analyzed 2,420,468 patients; 55.6% were hypertensive, with 8.5% meeting aRH criteria.
- aRH patients had higher rates of comorbidities like diabetes and heart failure.
- Controlled aRH patients were more often prescribed beta-blockers, diuretics, nitrates, and mineralocorticoid receptor antagonists.
Conclusions:
- Observed a lower aRH prevalence (8.5%) than previously reported.
- aRH patients exhibit a significant comorbidity burden.
- Differences in medication use, particularly mineralocorticoid receptor antagonists, highlight potential care improvement strategies for reducing cardiovascular risk.
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