Serum tryptase and drug hypersensitivity: why, how and what? A systematic review

Caroline Klingebiel1, Wahib Belhocine1, Joana Vitte2,3,4

  • 1Synlab Provence, Marseille.

Abstract

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Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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