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Updated: Jul 25, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Treatment with eptinezumab for migraine prevention in people with chronic migraine and medication-overuse headache: a
Amaal J Starling1, Melissa Kolbet2, Roger Cady3,4
1Mayo Clinic Arizona, Scottsdale, AZ, USA.
What Is This Summary About?:
This is a summary of three articles describing preventive treatment of migraine in participants with a diagnosis of both chronic migraine and medication-overuse headache in a study called PROMISE-2 (PRevention Of Migraine via Intravenous ALD403 Safety and Efficacy-2). People living with chronic migraine and medication-overuse headache have one of the most disabling, costly, and difficult-to-treat headache disorders.
What Were The Results?:
After preventive migraine treatment with eptinezumab (trade name Vyepti), participants with chronic migraine and medication-overuse headache experienced fewer migraine days, a reduced severity of migraine attacks, and a reduced use of acute medication. More participants receiving eptinezumab treatment no longer met the definition of either chronic migraine or medication-overuse headache throughout the study when compared with those receiving placebo.
What Do The Results Mean?:
Eptinezumab is beneficial for people who often use acute medication(s) due to frequent headache episodes or migraine attacks.
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