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Reversible leukoencephalopathy associated with organotin poisoning
Tinh Quang Dang1, Uyen Vy Doan2, Tri Dung Nguyen3
1Neurology Department, University Medical Center Ho Chi Minh City (University of Medicine and Pharmacy at Ho Chi Minh City), Ho Chi Minh City, Vietnam.
Clinical Toxicology (Philadelphia, Pa.)
|June 26, 2023
Summary
Organotin compounds can cause toxic leukoencephalopathy, affecting brain white matter. Brain MRI is crucial for diagnosing this condition in exposed individuals.
Area of Science:
- Neuroscience
- Toxicology
- Radiology
Background:
- Organotin compounds are extensively utilized in the plastic industry.
- Exposure to organotins can lead to neurological deficits.
Observation:
- A patient exposed to trimethyltin and dimethyltin presented with memory impairment, ataxia, apathy, tinnitus, skin changes, and psychomotor slowing.
- Magnetic resonance imaging (MRI) revealed diffuse bilateral white matter lesions.
Findings:
- Elevated tin levels were detected in the patient's blood and urine.
- The patient showed clinical, laboratory, and imaging improvements after removal from exposure and succimer treatment.
Implications:
- This case highlights the utility of brain MRI in diagnosing organotin-induced leukoencephalopathy.
- The role of chelation therapy in organotin toxicity requires further investigation.
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