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Updated: Jul 25, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Experimental and Computational Studies on RuII -Catalyzed C7-Allylation of Indolines with Allyl Bromide
Shiv Shankar Gupta1,2, Shivangi Gupta3, Manisha1,2
1C-H Activation & Phytochemistry Lab Chemical Technology Division, CSIR-IHBT, Palampur, HP 176 061, India.
Abstract:
The selective C7-allylation of indolines with allyl bromide under ruthenium catalysis has been revealed here. Under established reaction conditions, C7-allylation of various indolines, including drug compounds, was accomplished with good selectivity and yields. Based on combined experimental and density functional theory (DFT) studies, the olefin insertion route was energetically favorable among four possible pathways. Experimental and DFT studies further revealed that the C-H activation is a reversible rate-limiting step.
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