Increased release of lymphokines by allografted mouse spleen cells following concanavalin A stimulation

Using a test proposed in this laboratory for following macrophage "activation" (intracellular beta-glucuronidase content) and quantitative dilution studies, we have shown that lymphocytes from mice presensitized by a skin allograft release far more macrophage activating lympholines than do normal lymphocytes when non-specifically stimulated by concanavalin A. This difference may be due to latent metabolic changes of sensitized lymphocytes, but it may also express a modified balance among the various lymphocyte subpopulations within the spleen of grafted mice.