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Updated: Jul 25, 2025
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Iridium-Catalyzed Asymmetric Transfer Hydrogenation of 1-Aryl-1-alkylethenes with Ethanol
Xixia Tang1, Lu Qian2, Guixia Liu3
1School of Physical Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China.
Abstract:
Asymmetric transfer hydrogenation of 1-aryl-1-alkylethenes with ethanol was developed with a chiral (PCN)Ir complex as the precatalyst, featuring high enantioselectivities, good functional group tolerance, and operational simplicity. The method is further applied to formal intramolecular asymmetric transfer hydrogenation of alkenols without an external H-donor, producing a tertiary stereocenter and remote ketone group simultaneously. The utility of the catalytic system was highlighted by gram scale synthesis and the synthesis of the key precursor of (R)-xanthorrhizol.
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