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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Updated: Jul 25, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Suprathreshold Approaches to Mapping the Visual Field in Advanced Glaucoma.

Jonathan Denniss1, Allison M McKendrick2,3,4, Andrew Turpin3,5,6

  • 1School of Optometry and Vision Science, University of Bradford, Bradford, UK.

Translational Vision Science & Technology
|June 26, 2023
PubMed
Summary
This summary is machine-generated.

New suprathreshold tests can efficiently map advanced glaucoma visual field loss. The SupraThreshold Adaptive Mapping Procedure (STAMP) offers accurate and repeatable defect mapping in fewer presentations than conventional methods.

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Area of Science:

  • Ophthalmology
  • Visual Neuroscience
  • Medical Technology

Background:

  • Conventional perimetric sensitivity measurements are often unreliable in advanced glaucoma.
  • Accurate mapping of visual field defects is crucial for managing advanced glaucoma.

Purpose of the Study:

  • To evaluate suprathreshold tests on a high-density grid for efficient mapping of advanced visual field loss.
  • To compare the accuracy and repeatability of two suprathreshold procedures against interpolated Full Threshold 24-2.

Main Methods:

  • Simulations used data from 97 patients with mean deviation < -10 dB.
  • Two suprathreshold procedures, Spatial Binary Search (SpaBS) and SupraThreshold Adaptive Mapping Procedure (STAMP), were tested on a 1.5° grid.
  • STAMP used adaptive stimuli presentation and modified point status iteratively, stopping at 50%-100% of conventional test presentations.

Main Results:

  • SpaBS showed worse mean accuracy and repeatability than Full Threshold (P < 0.0001).
  • STAMP demonstrated slightly better mean accuracy compared to Full Threshold across all stopping criteria.
  • STAMP achieved similar mean repeatability to Full Threshold, with statistical significance for accuracy noted at 100% conventional test presentations.

Conclusions:

  • The SupraThreshold Adaptive Mapping Procedure (STAMP) can accurately and repeatably map advanced visual field defects.
  • STAMP requires as few as 50% of conventional perimetric test presentations.
  • Further research is needed to validate STAMP in human observers and for progressive visual field loss.