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Big data and reference intervals: rationale, current practices, harmonization and standardization prerequisites and
Luisa Martinez-Sanchez1,2,3, Fernando Marques-Garcia4, Yesim Ozarda5
1Clinical Biochemistry Department, Vall d'Hebron University Hospital, Barcelona, Spain.
Abstract:
Reference intervals are commonly used as a decision-making tool. In this review, we provide an overview on "big data" and reference intervals, describing the rationale, current practices including statistical methods, essential prerequisites concerning data quality, including harmonization and standardization, and future perspectives of the indirect determination of reference intervals using routine laboratory data.
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