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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Updated: Jul 25, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

IsoAnalytics: a single-cell proteomics web server.

Suzette N Palmer^1,2,3, Andrew Y Koh^1,4,5, Xiaowei Zhan^3,5

¹Division of Hematology/Oncology, Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Bioinformatics Advances

|June 26, 2023

Summary

IsoAnalytics is a new, free web server for analyzing single-cell proteomics data. This tool offers user-friendly data analysis and visualization for researchers without bioinformatics expertise, enhancing scientific discovery.

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Last Updated: Jul 25, 2025

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Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Published on: April 11, 2019

Area of Science:

Proteomics
Bioinformatics
Computational Biology

Background:

Single-cell proteomics offers high-resolution insights into biological processes.
Effective data analysis and visualization are critical for advancing scientific discovery.
Accessible software is needed for the broader scientific community.

Purpose of the Study:

To develop a user-friendly web server for single-cell proteomics data analysis.
To provide accessible tools for researchers without computational backgrounds.
To facilitate interactive data visualization for single-cell proteomics.

Main Methods:

Development of a web server named IsoAnalytics.
Implementation using Python for broad browser compatibility.
Integration with the Isoplexis single-cell technology platform.

Main Results:

IsoAnalytics enables direct analysis and interactive visualization of single-cell proteomics data.
The web server is accessible to users lacking bioinformatics expertise.
It serves as an open-sourced, free alternative for single-cell proteomics research.

Conclusions:

IsoAnalytics enhances research productivity by simplifying complex data analysis.
The tool democratizes access to advanced single-cell proteomics analysis.
It represents a significant contribution to the field of single-cell omics research.