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Synchronous Pleural and Peritoneal Mesothelioma: a Case Report and Narrative Review

Miguel Enrique Alberto Vilchez1, Eva Pachmayr1, Alexander Arnold2

  • 1Department of Surgery, Campus Virchow-Klinikum and Charité Campus Mitte, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

Indian Journal of Surgical Oncology
|June 26, 2023
PubMed

Insights

Synchronous pleural and peritoneal mesothelioma is rare, especially in children. A radical surgical approach combined with locoregional chemotherapy showed promising long-term results in a pediatric patient.

Area of Science:

  • Oncology
  • Pediatric Oncology
  • Surgical Oncology

Background:

  • Malignant mesotheliomas typically involve the pleura and spread locally.
  • Synchronous pleural and peritoneal mesothelioma is exceptionally rare, particularly in pediatric cases.
  • Limited data exists on metastatic spread and risk factors for mesothelioma.

Purpose of the Study:

  • To report a rare case of synchronous pleural and peritoneal mesothelioma in a child.
  • To evaluate the efficacy of a radical surgical approach with locoregional chemotherapy.
  • To highlight the need for standardized treatment guidelines for pediatric mesothelioma.

Main Methods:

  • A radical two-stage surgical resection was performed.
  • Locoregional chemotherapy was administered post-surgery.
  • Long-term follow-up was conducted to assess tumor recurrence.

Main Results:

  • The patient achieved no signs of tumor recurrence 9 years after treatment.
  • The radical surgical and chemotherapy approach demonstrated long-term efficacy in this case.
  • This case suggests a potential treatment strategy for rare pediatric mesotheliomas.

Conclusions:

  • Radical surgery combined with locoregional chemotherapy may be a viable treatment for synchronous pleural and peritoneal mesothelioma in children.
  • Further clinical studies are essential to validate this approach, define its limitations, and establish selection criteria.
  • The rarity of pediatric mesothelioma necessitates more research into standardized treatment protocols.
Keywords:
Cytoreductive SurgeryHIPECHITOCHyperthermic ChemotherapyPeritoneal MesotheliomaPleural Mesothelioma

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