Related Experiment Video

Updated: Jul 25, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

319

Association between the Triglyceride Glucose Index and Hyperuricemia in Patients with Primary Hypertension: A

Shanshan Liu1, Zhixian Zhou2, Miao Wu2

  • 1Department of Cardiology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China.

International Journal of Endocrinology
|June 26, 2023
PubMed

Insights

The triglyceride glucose (TyG) index is positively associated with hyperuricemia (HUA) in hypertensive patients. This link is stronger in individuals with grades 1-2 hypertension compared to grade 3 hypertension.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Syndrome Research
  • Nephrology

Background:

  • Hypertension is a global health concern.
  • Hyperuricemia (HUA) is linked to cardiovascular disease and kidney dysfunction.
  • The triglyceride glucose (TyG) index is emerging as a marker for insulin resistance and metabolic dysfunction.

Purpose of the Study:

  • To investigate the association between the TyG index and HUA in patients with grades 1-3 hypertension.
  • To explore potential differences in this association based on hypertension severity.

Main Methods:

  • A cross-sectional study of 1,707 hypertensive patients.
  • Calculation of the TyG index using Ln (triglycerides × fasting glucose/2).
  • Definition of HUA as uric acid ≥420 μmol/L.
  • Multivariate logistic regression, penalized spline regression, and generalized additive models were employed.
  • Stratified analyses were conducted for different hypertension grades.

Main Results:

  • A positive correlation was found between the TyG index and HUA (OR = 1.83; 95% CI: 1.40-2.39) after adjusting for covariates.
  • The correlation was linear across the TyG index range.
  • The association was stronger in patients with grades 1-2 hypertension (OR = 2.22; 95% CI: 1.44-3.42) than in those with grade 3 hypertension (OR = 1.58; 95% CI: 1.11-2.24).

Conclusions:

  • The TyG index is positively associated with HUA in hypertensive patients.
  • This association is more pronounced in patients with less severe hypertension (grades 1-2).
  • The findings suggest the TyG index may serve as a potential indicator for HUA risk in hypertensive populations.
Abstract

More Related Videos

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

800
Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

68.8K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
33
Oral Hypoglycemic Agents: Biguanides and Glitazones01:26

Oral Hypoglycemic Agents: Biguanides and Glitazones

Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
240
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
22
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
24
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.1K
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
306