Synthesis of tryptanthrin appended dispiropyrrolidine oxindoles and their antibacterial evaluation
Sruthi Sudheendran Leena1, Abdul Akhir2, Deepanshi Saxena2
1Department of Chemistry, University of Kerala Kariavattom Trivandrum-695581 India anideepthi@gmail.com.
Abstract:
The synthesis of sixteen tryptanthrin appended dispiropyrrolidine oxindoles, employing [3 + 2] cycloaddition of tryptanthrin-derived azomethine ylides with isatilidenes, and their detailed antibacterial evaluation is described. The in vitro antibacterial activities of the compounds were evaluated against ESKAPE pathogens and clinically relevant drug-resistant MRSA/VRSA strains, from which the bromo-substituted dispiropyrrolidine oxindole 5b (MIC = 0.125 μg mL-1) was found to be a potent molecule against S. aureus ATCC 29213 with a good selectivity index.
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