Related Experiment Video For Porphyria cutanea tarda
Updated: Jul 25, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Case Report: Treatment of porphyria cutanea tarda with low dose hydroxychloroquine
Andrew Awad1, Alexander Nirenberg2, Rodney Sinclair1,3,4
1Sinclair Dermatology, East Melbourne, VIC, 3002, Australia.
Abstract:
Background: Porphyria cutanea tarda (PCT) is a complex metabolic disease resulting from altered activity of the enzyme uroporphyrinogen decarboxylase (UROD) in the liver resulting in accumulation of uroporphyrin. PCT presents as a blistering photodermatitis with skin fragility, vesicles, scarring and milia. Case: We report a case of PCT in a 67-year-old man with hemochromatosis (HFE) gene mutation who, following a major syncopal episode in response to venesection was commenced on low dose hydroxychloroquine. Conclusions: Low dose hydroxychloroquine provided a safe and effective alternative to venesection in this patient who was needle phobic.
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