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Updated: Jul 25, 2025

A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
A data-driven optimization model to response to COVID-19 pandemic: a case study.
Amin Eshkiti1, Fatemeh Sabouhi1, Ali Bozorgi-Amiri1
1School of Industrial Engineering, College of Engineering, University of Tehran, Tehran, Iran.
This study developed a two-phase approach using artificial neural networks and stochastic programming to optimize hospital supply chains for COVID-19 patient management. The model efficiently allocates resources and minimizes disease spread, ensuring service continuity during disruptions.
Area of Science:
- Operations Research
- Healthcare Management
- Epidemiology
Background:
- COVID-19 has strained global healthcare systems, leading to hospitalization limitations and increased mortality risks.
- Efficient management of hospital resources, medication distribution, and waste is crucial during pandemics.
- Uncertainty in patient numbers and potential disruptions necessitate robust supply chain network design.
Purpose of the Study:
- To design an optimized supply chain network for hospitalizing COVID-19 patients.
- To efficiently distribute medications and medical supplies while managing hospital waste.
- To address uncertainty in patient demand and facility disruptions through a data-driven approach.
Main Methods:
- A two-phase approach combining Artificial Neural Networks (ANNs) for demand forecasting and K-Means for scenario reduction.
- Development of a multi-objective, multi-period, two-stage stochastic programming model.
- Incorporation of objectives: maximizing allocation-to-demand ratio, minimizing disease spread risk, and minimizing transportation time.
Main Results:
- Identified optimal locations for temporary facilities in high-density areas lacking existing infrastructure.
- Temporary hospitals can meet up to 2.6% of total demand, alleviating pressure on existing facilities.
- The proposed model maintains an ideal allocation-to-demand ratio even during disruptions.
Conclusions:
- The study provides an effective framework for pandemic-related healthcare supply chain management.
- Temporary facilities are vital for maintaining healthcare service levels during demand surges.
- The stochastic programming model successfully mitigates risks associated with demand uncertainty and facility disruptions.
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