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Microscopic colitis is a risk factor for low bone density: a systematic review and meta-analysis
Anett Rancz1,2, Brigitta Teutsch1,3, Marie Anne Engh1
1Centre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Microscopic colitis (MC) significantly increases the risk of low bone density (LBD). Patients with MC have a twofold higher chance of developing LBD, indicating a need for bone density screening.
Area of Science:
- Gastroenterology
- Endocrinology
- Rheumatology
Background:
- Microscopic colitis (MC) is a chronic inflammatory bowel disease causing watery diarrhea and reduced quality of life.
- Limited evidence suggests a potential association between MC and low bone density (LBD).
Purpose of the Study:
- To determine if MC is a risk factor for LBD.
- To quantify the prevalence of LBD in patients diagnosed with MC.
Main Methods:
- A systematic review and meta-analysis were conducted.
- Searched five databases (PubMed, Embase, Cochrane, Scopus, Web of Science) up to October 16, 2021.
- Used random-effect models and GRADE guidelines for analysis.
Main Results:
- MC is associated with a twofold increased odds of LBD (OR=2.13).
- Prevalence of LBD, osteopenia, and osteoporosis in MC patients was 68%, 51%, and 11%, respectively.
- The certainty of evidence was rated as very low.
Conclusions:
- MC is linked to a doubled risk of low bone density.
- Recommend screening MC patients for bone mineral density at diagnosis.
- Further prospective studies are necessary to confirm findings.
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