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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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IgG4-related disease: a case report.
Silvia de Las Heras Flórez1, Mercedes Carretero Pérez2, Carmen Teresa Sanz Díaz2
1Nuestra Señora de la Candelaria University Hospital Ringgold standard institution - Core-Protein Unit, Carretera General del Rosario 145, 38010 Santa Cruz of Tenerife, Spain.
Advances in Laboratory Medicine
|June 26, 2023
Summary
Immunoglobulin G4-related disease (IgG4-RD) can affect any organ. This case highlights how elevated serum IgG4 levels can guide diagnosis in symptomatic patients, aiding timely treatment.
Area of Science:
- Immunology
- Rheumatology
- Pathology
Background:
- Immunoglobulin G4-related disease (IgG4-RD) is a recently described fibroinflammatory condition.
- It has the potential to affect virtually any organ system in the body.
- Diagnosis relies on integrating clinical, histopathological, and serological findings.
Observation:
- A symptomatic patient presented with clinical manifestations suggestive of IgG4-related disease.
- Diagnostic workup included assessment of clinical presentation and histopathological examination.
- Serum levels of Immunoglobulin G4 (IgG4) were significantly elevated.
Findings:
- The elevated serum IgG4 levels were a key factor in confirming the diagnosis of IgG4-RD.
- This case underscores the utility of serum IgG4 measurement in diagnosing IgG4-RD.
- The patient's symptoms were directly linked to the IgG4-RD diagnosis.
Implications:
- Accurate and timely diagnosis of IgG4-RD is crucial for effective management.
- Elevated serum IgG4 serves as a valuable biomarker for IgG4-RD.
- This case emphasizes the importance of considering IgG4-RD in patients with unexplained multi-organ involvement.
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