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COVID-19 Immune Response In Adults Post Measles-Rubella Vaccination.

Suwoyo Suwoyo1, Erna Rahma Yani1, Koekoeh Hardjito1

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Vacunas
|June 26, 2023
PubMed
Summary

The measles, mumps, and rubella (MR) vaccine did not significantly increase SARS-CoV-2 immunoglobulin levels in adults who had already received two doses of the COVID-19 vaccine. Antibody levels remained low post-vaccination.

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IgG-SARS CoV-2IgM-SARS CoV-2MR Vaccine

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Area of Science:

  • Immunology
  • Vaccinology
  • Infectious Diseases

Background:

  • The COVID-19 pandemic necessitated rapid vaccine development and deployment.
  • Understanding the potential interactions between different vaccination schedules is crucial for public health.
  • Measles, mumps, and rubella (MR) vaccination is a common immunization, and its effect on existing SARS-CoV-2 immunity warrants investigation.

Purpose of the Study:

  • To investigate the impact of measles, mumps, and rubella (MR) vaccination on SARS-CoV-2 immunoglobulin levels.
  • To assess changes in anti-SARS-CoV-2 IgG and IgM antibody titers following MR vaccination in a vaccinated adult population.

Main Methods:

  • A quasi-experimental study with a pre-post test design was conducted.
  • The study included 30 adult participants who had completed the second dose of a SARS-CoV-2 vaccine.
  • Immunoglobulin levels (IgG and IgM) against SARS-CoV-2 were measured before and after MR vaccination.

Main Results:

  • Most participants (60%) showed an increase in IgM levels, while 46.6% showed an increase in anti-SARS-CoV-2 IgG levels.
  • The administration of the MR vaccine did not demonstrate a significant effect on increasing anti-SARS-CoV-2 IgG and IgM levels.
  • The observed increases in antibody levels were generally low in the pre- and post-vaccination tests.

Conclusions:

  • MR vaccination in adults previously vaccinated against SARS-CoV-2 elicited a minimal immune response in terms of IgG and IgM antibody levels.
  • The findings suggest limited cross-reactivity or synergistic effects between MR vaccination and existing SARS-CoV-2 immunity in this cohort.
  • Further research may be needed to explore the long-term implications and potential immune interactions.