Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinical experience with injectable collagen for vocal fold augmentation.

C N Ford, D M Bless

    The Laryngoscope
    |August 1, 1986
    PubMed
    Summary

    Injectable collagen (Zyderm) is safe and effective for glottic insufficiency, with best results in unilateral vocal fold paralysis. Proper injection technique is crucial for optimal vocal fold vibration and long-term outcomes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Retinopathy develops at similar glucose levels but higher HbA<sub>1c</sub> levels in people with black African ancestry compared to white European ancestry: evidence for the need to individualize HbA<sub>1c</sub> interpretation.

    Diabetic medicine : a journal of the British Diabetic Association·2020
    Same author

    Impact of mismatches in HbA<sub>1c</sub> vs glucose values on the diagnostic classification of diabetes and prediabetes.

    Diabetic medicine : a journal of the British Diabetic Association·2019
    Same author

    Racial differences in performance of HbA<sub>1c</sub> for the classification of diabetes and prediabetes among US adults of non-Hispanic black and white race.

    Diabetic medicine : a journal of the British Diabetic Association·2019
    Same author

    In vivo markers of inflammatory response in recent-onset schizophrenia: a combined study using [(11)C]DPA-713 PET and analysis of CSF and plasma.

    Translational psychiatry·2016
    Same author

    SSB taxes and diet quality in US preschoolers: estimated changes in the 2010 Healthy Eating Index.

    Pediatric obesity·2016
    Same author

    Ten-year beverage intake trends among US preschool children: rapid declines between 2003 and 2010 but stagnancy in recent years.

    Pediatric obesity·2015

    Area of Science:

    • Otolaryngology
    • Vocal Fold Physiology
    • Biomaterials

    Background:

    • Glottic insufficiency can significantly impair vocal quality and function.
    • Injectable materials offer a minimally invasive treatment option for vocal fold augmentation.

    Purpose of the Study:

    • To evaluate the safety and efficacy of Zyderm Collagen Implant for treating glottic insufficiency.
    • To identify factors influencing treatment outcomes and optimal injection techniques.

    Main Methods:

    • A cohort of 54 patients with glottic insufficiency received vocal fold injections of Zyderm Collagen Implant.
    • Videostroboscopy, maximum phonation time, and transglottic airflow were used to assess glottic function and efficiency.
    • Patients were followed for up to 2 years, with subgroup analysis based on diagnosis.

    Main Results:

    • Injectable collagen demonstrated safety and effectiveness in improving glottic function and vocal quality.
    • Treatment responses stabilized by 3 months and showed minimal decline over 1 year.
    • Optimal outcomes were observed in patients with unilateral vocal fold paralysis; scarred vocal folds responded less favorably.
    • Correct injection plane (vocal ligament) is critical for efficacy and preventing implant resorption or impaired vibration.

    Conclusions:

    • Zyderm Collagen Implant is a safe and effective treatment for glottic insufficiency, particularly in cases of unilateral vocal fold paralysis.
    • Injection technique significantly impacts results, with the vocal ligament plane yielding the best outcomes.
    • Further research into cross-linked collagen preparations may reduce hypersensitivity reactions.

    Related Experiment Videos