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Hematology profile analysis in coronavirus disease 2019 (COVID-19) patients

Felisia Setio1, Darwati Muhadi1,2, Asvin Nurulita1,2

  • 1Hasanuddin University, Makassar, Indonesia.

Advances in Laboratory Medicine
|June 26, 2023
PubMed

Insights

Hematological parameters can predict COVID-19 severity. Eosinophil count may indicate infectivity in patients. This study analyzed hematology profiles in relation to COVID-19 severity and Ct values in Makassar, Indonesia.

Area of Science:

  • Hematology
  • Infectious Diseases
  • COVID-19 Research

Background:

  • Hematological parameters serve as potential markers for assessing COVID-19 severity.
  • Comorbidities are recognized risk factors contributing to severe COVID-19 outcomes.
  • Previous studies have not explored hematology profiles in relation to severity, comorbidity, and viral load (Ct value) in Makassar, Indonesia.

Purpose of the Study:

  • To investigate differences in hematological profiles based on COVID-19 severity.
  • To examine hematological profile variations concerning patient comorbidities.
  • To determine the correlation between hematological parameters and the Ct value of SARS-CoV-2.

Main Methods:

  • Retrospective, cross-sectional study design.
  • Inclusion of confirmed COVID-19 patients hospitalized between June and August 2020.
  • Data collection from Hospital Information System, including hematology profile, Ct value, comorbidity, and severity.

Main Results:

  • Severe COVID-19 patients exhibited significantly higher White Blood Cells (WBC), Red Cell Distribution Width (RDW), neutrophil, monocyte counts, and Neutrophil Lymphocyte Ratio (NLR) compared to mild-moderate cases (p<0.05).
  • Severe cases also showed significantly lower Red Blood Cells (RBC), hemoglobin, hematocrit, lymphocyte, and thrombocyte counts (p<0.05).
  • Hematological profiles did not significantly differ based on comorbidity and showed no significant correlation with Ct value, except for eosinophil count (r=0.161; p=0.018).

Conclusions:

  • Hematological profiles can serve as predictive indicators for COVID-19 severity.
  • Eosinophil count may be a potential predictor of infectivity in COVID-19 patients.
Abstract

Keywords:
COVID-19Ct valuecomorbidityhematology profileinflammationseverity

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