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Systemic sclerosis associated with primary sclerosing cholangitis and hyperthyroidism: a case report.

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Systemic sclerosis patients may develop other immune-mediated diseases like primary sclerosing cholangitis and hyperthyroidism. Early diagnosis and treatment led to a patient

Keywords:
Systemic sclerosishyperthyroidismprimary sclerosing cholangitis

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Area of Science:

  • Immunology
  • Gastroenterology
  • Endocrinology

Background:

  • Systemic sclerosis (SSc) is an autoimmune disease.
  • Co-occurrence of SSc with other immune-mediated conditions is possible.
  • Clinical presentation of SSc can overlap with other autoimmune disorders.

Purpose of the Study:

  • To highlight the association between systemic sclerosis and other immune-mediated diseases.
  • To report a case of concurrent primary sclerosing cholangitis and hyperthyroidism in a patient with SSc.
  • To emphasize the importance of considering co-existing immune-mediated diseases in SSc patients.

Main Methods:

  • Case report of a 43-year-old female patient.
  • Review of patient's medical history, including SSc diagnosis.
  • Diagnostic investigations including laboratory tests, magnetic resonance cholangiopancreatography, ultrasound, and computed tomography scan.

Main Results:

  • The patient presented with symptoms including jaundice, dark urine, dyspnea, fatigue, arthralgia, weight loss, and amenorrhea.
  • She was diagnosed with primary sclerosing cholangitis and hyperthyroidism.
  • The patient showed good recovery after treatment and follow-up.

Conclusions:

  • Immune-mediated diseases can manifest concurrently or sequentially.
  • Common underlying immunological dysfunction can link these conditions.
  • Vigilance for co-existing immune-mediated diseases is crucial in managing SSc patients.