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Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
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Related Experiment Video

Updated: Jul 25, 2025

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
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NOVEL METHOD FOR VISUALIZING PERIPHERAL RETINAL STRUCTURES WITH MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY.

Frank L Brodie1, Henry Feng1, William Raynor1

  • 1Departments of Ophthalmology, and.

Retinal Cases & Brief Reports
|June 26, 2023
PubMed
Summary
This summary is machine-generated.

Intraoperative optical coherence tomography (OCT) with a Goldmann lens enables visualization of peripheral retinal pathology. This method aids surgeons in identifying conditions like retinoschisis and retinal detachment.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Surgery

Background:

  • Peripheral retinal imaging with optical coherence tomography (OCT) presents significant challenges.
  • Accurate visualization of the peripheral retina is crucial for diagnosing and managing various ocular conditions.

Purpose of the Study:

  • To describe a novel method for intraoperative OCT of the peripheral retina.
  • To evaluate the utility of a microscope-integrated OCT system with a Goldmann lens for peripheral imaging.

Main Methods:

  • Utilized an investigational microscope-integrated OCT system with real-time 4D volumetric imaging.
  • Employed a Goldmann style mirrored contact lens intraoperatively in three patients.
  • Captured peripheral retinal images during surgical procedures.

Main Results:

  • Successfully visualized peripheral retinal structures, including retinoschisis.
  • Identified a retinal break using the described peripheral OCT method.
  • Detected areas of focal retinal detachment in the peripheral retina.

Conclusions:

  • Intraoperative OCT combined with a Goldmann lens provides surgeons enhanced visualization of peripheral retinal pathology.
  • This technique facilitates the evaluation of peripheral retinal conditions not easily assessed with conventional OCT.
  • The described method offers a valuable tool for improving surgical outcomes in retinal procedures.