Single-Molecule Fluorescence Investigations of Solute Transport Dynamics in Nanostructured Membrane Separation...

Many materials used for membrane separations are composed of nanoscale structures such as pores and domains. Such nanostructures often control the solute permeability and selectivity of the separation membranes. Thus, for future development of highly efficient separation membranes, it is important to understand the structural and chemical properties of these nanostructures and also their influences on solute transport dynamics. For the last two decades, single-molecule fluorescence techniques have been used to measure the detailed dynamics of solute molecules diffusing in various nanostructured materials, giving valuable insights into molecular transport mechanisms influenced by nanoscale material heterogeneity. This Perspective discusses recent single-molecule fluorescence studies on solute diffusion in materials relevant to membrane separations, including dense polymer films and nanoporous materials. These studies have revealed the formation and properties of nanostructures and unique transport dynamics of solute molecules manipulated by their confinement and partitioning to the nanostructures, which play key roles in membrane separations. This Perspective will also point out scientific challenges toward a thorough understanding of molecular-level mechanisms in membrane separations.