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Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
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The primary cardiomyopathy of systemic sclerosis on cardiovascular magnetic resonance imaging

Sanya Chhikara1, Adinan Kanda1, Fredrick M Ogugua1

  • 1Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, 420 Delaware Street SE, MMC 508, Minneapolis, MN 55455, USA.

European Heart Journal. Cardiovascular Imaging
|June 26, 2023
PubMed

Insights

The primary cardiomyopathy of systemic sclerosis (SSc) affects 21% of patients. This condition is linked to increased long-term risks of death or major adverse cardiac events (MACE), highlighting the importance of cardiac assessment in SSc patients.

Area of Science:

  • Cardiology
  • Rheumatology
  • Medical Imaging

Background:

  • Cardiac involvement in systemic sclerosis (SSc) can be primary or secondary.
  • The prevalence and prognostic significance of primary SSc cardiomyopathy remain unclear.
  • Cardiovascular magnetic resonance (CMR) is a valuable tool for diagnosing cardiac conditions.

Purpose of the Study:

  • To determine the prevalence of primary SSc cardiomyopathy.
  • To characterize its features using CMR.
  • To investigate its association with long-term adverse cardiac outcomes.

Main Methods:

  • Retrospective cohort study of SSc patients undergoing clinical CMR.
  • Analysis of CMR findings, including left ventricular ejection fraction and late gadolinium enhancement (LGE).
  • Assessment of the association between primary SSc cardiomyopathy and the incidence of death or major adverse cardiac events (MACE).

Main Results:

  • The prevalence of primary SSc cardiomyopathy was 21%.
  • A distinct LGE phenotype was observed in one-third of these patients.
  • Primary SSc cardiomyopathy was associated with a 2-fold increased risk of death or MACE over a median follow-up of 3.6 years.

Conclusions:

  • The primary cardiomyopathy of SSc occurs in 21% of patients and is associated with a distinct LGE pattern in a subset.
  • Primary SSc cardiomyopathy is an independent predictor of worse long-term outcomes, including death or MACE.
Abstract

Keywords:
cardiomyopathycardiovascular magnetic resonance imagingprognosissclerodermasystemic sclerosis

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