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Hepatic dysfunction in childhood malaria.

A Patwari, S Aneja, A M Berry

    Archives of Disease in Childhood
    |February 1, 1979
    PubMed
    Summary
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    Pediatric Plasmodium vivax malaria commonly causes temporary liver dysfunction, indicated by elevated liver enzymes. These liver function markers return to normal levels after antimalarial treatment in young children.

    Area of Science:

    • Pediatric Hepatology
    • Infectious Diseases
    • Malariology

    Background:

    • Plasmodium vivax malaria is a significant global health concern, particularly in pediatric populations.
    • Hepatic involvement in malaria, even with P. vivax, can lead to deranged liver function tests.
    • Understanding the impact of P. vivax malaria on liver health in young children is crucial for effective management.

    Purpose of the Study:

    • To investigate the hepatic function in children under 3 years old with Plasmodium vivax malaria.
    • To assess changes in liver enzymes during acute malaria and after treatment.
    • To determine the prevalence and transient nature of malaria-associated hepatic dysfunction.

    Main Methods:

    • Studied 80 children under 3 years with P. vivax malaria.

    Related Experiment Videos

  • Measured serum aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase levels.
  • Assessed liver function during acute infection and 6 weeks post-antimalarial treatment.

    • Main Results:

    • Elevated AST, ALT, and alkaline phosphatase were observed in 68%, 39%, and 46% of cases, respectively.
    • Higher AST than ALT levels were noted, with elevated enzymes correlating with hepatomegaly.
    • Liver enzyme levels normalized 6 weeks after treatment, indicating transient hepatic dysfunction.

    Conclusions:

    • Transient hepatic dysfunction is a common manifestation of childhood malaria, including P. vivax infections.
    • P. vivax malaria significantly impacts liver function in young children.
    • Antimalarial treatment effectively resolves malaria-induced hepatic derangements.