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Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
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Structure-function coupling increases during interictal spikes in temporal lobe epilepsy: A graph signal processing

I Rigoni1, J Rué Queralt2, K Glomb3

  • 1EEG and Epilepsy Unit, University Hospital and Faculty of Medicine of Geneva, University of Geneva, Switzerland.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|June 26, 2023
PubMed
Summary
This summary is machine-generated.

In temporal lobe epilepsy (TLE), brain network integration, not segregation, dominates during interictal epileptic discharges (IEDs). This shift towards integration is localized in specific brain regions, offering new insights into epilepsy mechanisms.

Keywords:
EEGGraph signal processingStructure–function couplingTemporal lobe epilepsy

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Area of Science:

  • Neuroscience
  • Epilepsy Research
  • Brain Network Analysis

Background:

  • Understanding structure-function coupling is crucial for deciphering brain disorders.
  • Temporal lobe epilepsy (TLE) provides a model to study these couplings during interictal epileptic discharges (IEDs).

Purpose of the Study:

  • To investigate the relationship between brain structure and function during IEDs in TLE.
  • To differentiate between integrated and segregated brain network activity during epileptic events.

Main Methods:

  • Utilized graph signal processing on structural connectomes from 17 TLE patients.
  • Decomposed IEDs into spatial maps (network harmonics) representing integration (smooth maps) and segregation (coarse maps).
  • Quantified the energy of IEDs coupled (Xc) and decoupled (Xd) from structural connectivity over time.

Main Results:

  • IED energy coupled to structure (Xc) increased around the first IED peak, unlike decoupled energy (Xd).
  • Ipsilateral mesial regions, including the hippocampus, showed significant and increasing coupling to structure during IEDs.
  • Whole-brain analysis revealed a shift from segregation to integration during IEDs.

Conclusions:

  • During TLE IEDs, brain-wide segregation is replaced by integrative processes.
  • Epileptogenic networks in TLE exhibit increased reliance on long-range couplings during IEDs.
  • Integration mechanisms are localized in ipsilateral mesial temporal regions during TLE IEDs.