Related Experiment Video

Updated: Jul 25, 2025

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

4.5K

[Drug toxic hepatopathy - an underestimated danger]

Elke Roeb

    Deutsche Medizinische Wochenschrift (1946)
    |June 26, 2023
    PubMed

    Insights

    Diagnosing drug-induced liver injury (DILI) presents challenges due to varied symptoms. This review covers DILI diagnosis, therapies, and special cases, utilizing the RUCAM score for causality assessment.

    Area of Science:

    • Hepatology
    • Clinical Pharmacology
    • Toxicology

    Context:

    • Drug-induced toxic hepatopathies and drug-induced liver injury (DILI) pose diagnostic challenges due to diverse clinical presentations.
    • Understanding the mechanisms and clinical implications of DILI is crucial for patient management.

    Purpose:

    • To elucidate the diagnostic approaches for DILI.
    • To outline current therapeutic strategies for drug-induced liver injury.
    • To discuss emerging patterns of DILI associated with newer drug classes like DOACs, IBD drugs, and tyrosine kinase inhibitors.

    Summary:

    • This article details the diagnosis and management of DILI, highlighting its varied clinical manifestations.
    • It explores specific etiological considerations for DILI, including risks associated with DOACs, IBD medications, and tyrosine kinase inhibitors.
    • The Roussel Uclaf Causality Assessment Method (RUCAM) score is presented as a key tool for evaluating the likelihood of drug-induced liver damage.

    Impact:

    • Provides clinicians with a framework for diagnosing and managing DILI.
    • Enhances understanding of DILI associated with novel therapeutic agents.
    • Supports evidence-based clinical decision-making in cases of suspected drug-induced liver injury.

    More Related Videos

    Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications07:23

    Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications

    Published on: October 20, 2023

    1.4K
    Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure08:25

    Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

    Published on: June 5, 2020

    6.8K

    Related Concept Videos

    Hepatic Drug Excretion: Influencing Factors01:16

    Hepatic Drug Excretion: Influencing Factors

    The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
    164
    Enhanced Elimination of Poison01:26

    Enhanced Elimination of Poison

    Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
    Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
    Renal excretion is the...
    550
    Depressants01:28

    Depressants

    Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
    Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
    144
    Factors Affecting Drug Response: Overview01:21

    Factors Affecting Drug Response: Overview

    When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
    2.0K
    Toxic Reactions: Overview01:26

    Toxic Reactions: Overview

    When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
    Toxicity falls into two primary categories: local and systemic.
    Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
    In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
    1.0K
    Hepatic Drug Excretion: Enterohepatic Cycling01:17

    Hepatic Drug Excretion: Enterohepatic Cycling

    Enterohepatic cycling involves the active secretion of drugs and their metabolites into the bile via transporters in the canalicular membrane of hepatocytes. This secretion is an integral part of the digestive process, releasing these substances into the gastrointestinal (GI) tract.
    Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
    1.6K