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Polyplex designs for improving the stability and safety of RNA therapeutics

Satoshi Uchida1, Chun Yin Jerry Lau2, Makoto Oba3

  • 1Department of Advanced Nanomedical Engineering, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan; Medical Chemistry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-cho, Sakyo-ku, Kyoto, 606-0823, Japan; Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki, 210-0821, Japan.

Advanced Drug Delivery Reviews
|June 26, 2023
PubMed

Keywords:
CytotoxicityInnate immune responseNanoparticlePolycationPolyion exchange reactionRNA engineeringRibonucleaseSiRNAmRNA

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