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Updated: Jul 25, 2025

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
Published on: October 3, 2019
Erythromelalgia. Part I: Pathogenesis, clinical features, evaluation, and complications
Elena Gonzalez Caldito1, Subuhi Kaul1, Natalia Gonzalez Caldito2
1Division of Dermatology, John H Stroger Hospital of Cook County, Chicago, Illinois.
Abstract:
Erythromelalgia is a rare pain disorder that is underrecognized and difficult-to-treat. It is characterized by episodes of extremity erythema and pain that can be disabling; it may be genetic, related to an underlying systemic disease, or idiopathic. Considering the prominent cutaneous features characteristic of the condition, dermatologists can play an important role in early recognition and limitation of morbidity. The first article in this 2-part continuing medical education series reviews the epidemiology, pathogenesis, clinical manifestations, evaluation, and complications.
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