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Transducing compressive forces into cellular outputs in cancer and beyond
Céline Schmitter1,2,3, Mickaël Di-Luoffo1,2, Julie Guillermet-Guibert4,2
1CRCT, Université de Toulouse, Inserm, CNRS, Université Toulouse-III Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Toulouse, France.
Life Science Alliance
|June 26, 2023
Summary
Cells respond to mechanical forces like compression via mechanotransduction, activating signaling pathways. This review explores compression
Area of Science:
- Cellular Biology
- Biophysics
- Mechanobiology
Background:
- Cells perceive and react to mechanical forces (e.g., compression) through mechanotransduction.
- This process involves biochemical signaling pathways.
- Compression influences cell behavior and tissue homeostasis, and is implicated in diseases like cancer.
Purpose of the Study:
- To review current knowledge on compression-induced cell signaling pathways.
- To summarize cellular responses to compression in physiological and pathological contexts.
- To highlight the role of compression in conditions such as solid cancers.
Main Methods:
- Literature review of studies on mechanotransduction and cell signaling.
- Analysis of research on compression-induced cellular responses.
- Synthesis of information on physiological and pathological roles of compression.
Main Results:
- Compressive forces selectively modulate cell behavior.
- Mechanotransduction integrates mechanical stimuli into biochemical signals.
- Compression affects both directly compressed and neighboring cells.
Conclusions:
- Understanding compression-induced signaling is crucial for tissue homeostasis and disease.
- Further research is needed to fully elucidate these pathways in various conditions.
- This review consolidates scattered knowledge on cellular responses to compression.
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