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Regulatory mechanisms and therapeutic potential of JAB1 in neurological development and disorders

Yu Yang1,2, Ruying Song1,2, Yiming Gao1,2

  • 1Department of Psychiatry, Jining Medical University, Jianshe South Road No. 45, Jining, Shandong, China.

Molecular Medicine (Cambridge, Mass.)
|June 26, 2023
PubMed

Insights

c-Jun activation domain binding protein-1 (JAB1) is a key regulator in cells, impacting both cancer and neurological functions. This review details JAB1

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Oncology

Background:

  • c-Jun activation domain binding protein-1 (JAB1) is a multifunctional protein regulating AP-1 transcriptional activity and the COP9 signalosome complex.
  • JAB1 is recognized as an oncoprotein involved in tumor development.
  • Emerging evidence highlights JAB1's crucial roles in neurological development and disorders.

Purpose of the Study:

  • To review the general features and expression regulation of the JAB1 gene and protein.
  • To summarize the functional roles and regulatory mechanisms of JAB1 in neurodevelopmental processes.
  • To discuss JAB1's involvement in neurological disease pathogenesis and potential therapeutic strategies.

Main Methods:

  • Literature review of JAB1's functions in cellular processes.
  • Analysis of JAB1's role in neurodevelopmental pathways (neuronal differentiation, synaptic morphogenesis, myelination, hair cell development).
  • Examination of JAB1's contribution to neurological disorders (Alzheimer's disease, multiple sclerosis, neuropathic pain, peripheral nerve injury).

Main Results:

  • JAB1 regulates key neurodevelopmental processes including neuronal differentiation, synapse formation, and myelination.
  • JAB1 is implicated in the pathogenesis of major neurological conditions such as Alzheimer's disease and multiple sclerosis.
  • Drug development targeting JAB1 presents a promising avenue for treating neurological disorders.

Conclusions:

  • JAB1 is a critical regulator with dual roles in oncogenesis and neurobiology.
  • Understanding JAB1's complex functions is essential for advancing neurodevelopmental research and neurological disease treatment.
  • Targeting JAB1 offers potential therapeutic benefits for various neurological conditions.
Keywords:
COP9 signalosomeNeurodevelopmentNeurological disordersRegulatory mechanismsc-Jun activation domain binding protein-1

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