Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

607
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
607
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

303
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
303
Neural Regulation01:37

Neural Regulation

39.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.6K
Human Genetics01:28

Human Genetics

625
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
625

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeted long-read sequencing enables comprehensive analysis of the genetic and epigenetic landscape of inherited myopathies.

Nature communications·2026
Same author

<i>GCH1</i> p.Ser80Asn Confers Risk for Parkinson's Disease in East Asian Populations.

medRxiv : the preprint server for health sciences·2026
Same author

Large-scale functional annotation establishes a reference framework for human <i>LRRK2</i> variants.

medRxiv : the preprint server for health sciences·2026
Same author

Can Multiple Sclerosis be Managed Over a Lifetime? A Rare 72-Year Journey of Pediatric-Onset to Secondary Progressive Multiple Sclerosis.

Clinical case reports·2026
Same author

Celebrating the legacy of two decades of Parkinson's disease research in South Africa.

Journal of Parkinson's disease·2026
Same author

A Practice Framework for Genetic Testing in Asymptomatic Relatives of Patients With Creutzfeldt-Jakob Disease: Experience and Insights From Israel.

European journal of neurology·2026

Related Experiment Video

Updated: Jul 25, 2025

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

7.6K

Genetic Testing in Parkinson's Disease.

Gian Pal1, Lola Cook2, Jeanine Schulze2

  • 1Department of Neurology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

Movement Disorders : Official Journal of the Movement Disorder Society
|June 27, 2023
PubMed
Summary
This summary is machine-generated.

Genetic testing for Parkinson's disease (PD) is expanding, but lacks clear guidelines. Research is needed to address key gaps and controversies for appropriate testing and counseling strategies.

Keywords:
Parkinson's diseaseattitudesgenetic counselinggenetic testing

More Related Videos

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes
08:42

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes

Published on: July 18, 2008

16.1K
Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease
10:32

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

Published on: June 17, 2013

55.3K

Related Experiment Videos

Last Updated: Jul 25, 2025

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

7.6K
Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes
08:42

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes

Published on: July 18, 2008

16.1K
Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease
10:32

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

Published on: June 17, 2013

55.3K

Area of Science:

  • Neurogenetics
  • Clinical Genetics
  • Parkinson's Disease Research

Background:

  • Genetic testing for Parkinson's disease (PD) is increasingly prevalent across clinical, research, and direct-to-consumer platforms.
  • Despite advancements in testing methodologies and accessibility, the clinical utility is limited by the absence of proven gene-targeted therapies, though clinical trials are ongoing.

Purpose of the Study:

  • To identify and analyze critical gaps and controversies in genetic testing for Parkinson's disease.
  • To inform the development of much-needed guidelines for genetic testing and counseling in PD.

Main Methods:

  • A comprehensive review of recent scientific literature was conducted.
  • Key gaps and controversies surrounding PD genetic testing were identified and analyzed.

Main Results:

  • Several critical gaps and controversies were identified, including the appropriateness of testing without immediate medical actionability, ethnic considerations in testing, long-term outcomes of presymptomatic testing, and resource/cost-benefit analyses for clinical genetic testing.
  • Many identified issues remain underexplored or poorly defined in existing literature.

Conclusions:

  • Addressing identified gaps and controversies is essential for developing consensus and guidelines for Parkinson's disease genetic testing and counseling.
  • Guidelines must adopt a multidisciplinary approach, considering cultural, geographic, and socioeconomic factors to ensure equitable access and appropriate utilization of genetic testing.