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Related Experiment Video

Updated: Jul 25, 2025

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Published on: June 17, 2015

Astrocyte and Neuronal Panx1 Support Long-Term Reference Memory in Mice.

Price Obot^1,2, Galadu Subah¹, Antonia Schonwald¹

¹Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY, USA.

|June 27, 2023

Summary

This summary is machine-generated.

Pannexin 1 (Panx1) channels are crucial for long-term spatial memory consolidation. Deleting Panx1 impairs memory formation, highlighting its role in neuron-glia interactions and synaptic plasticity.

Keywords:

long-term potentiation pannexin radial maze spatial memory synaptic plasticity

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Last Updated: Jul 25, 2025

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Published on: June 17, 2015

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

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Published on: June 22, 2021

Area of Science:

Neuroscience
Molecular Biology
Cell Biology

Background:

Pannexin 1 (Panx1) forms plasma membrane channels permeable to signaling molecules.
Panx1 channel activation is linked to neurological disorders.
Its physiological role in learning and memory is largely unexplored.

Purpose of the Study:

To investigate the role of Panx1 in working and reference memory.
To determine the contribution of neuronal and astrocyte Panx1 to memory formation.
To explore the impact of Panx1 deletion on synaptic plasticity in the hippocampus.

Main Methods:

Utilized Panx1 transgenic mice with global and cell-type specific deletions.
Assessed spatial working and reference memory using the eight-arm radial maze.
Performed field potential recordings in hippocampal slices to analyze synaptic plasticity (LTP/LTD).

Main Results:

Panx1-null mice exhibited deficits in long-term spatial reference memory, but not working memory.
Both astrocyte and neuronal Panx1 were found to contribute to memory consolidation.
Hippocampal slices from Panx1-null mice showed attenuated long-term potentiation and depression at Schaffer collateral-CA1 synapses.

Conclusions:

Neuronal and astrocyte Panx1 channels are essential for the development and maintenance of long-term spatial reference memory.
Panx1 plays a significant role in activity-dependent neuron-glia interactions influencing memory.
Panx1 channels are critical for hippocampal synaptic plasticity underlying spatial memory.