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Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

14
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
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Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

26
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
26

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Aortic Growth After Isolated Aortic Valve Repair in Patients With Aortic Regurgitation Without Primary Aneurysm Indication.

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Home-based, online-monitored high-intensity interval training improves fitness in patients with tetralogy of Fallot: a randomised controlled trial.

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Prevalence, Aetiology, and Progression of Mitral Valve Regurgitation in Patients Diagnosed with Ascending Aortic Aneurysm.

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Reframing atherothrombosis through the inflammation hypothesis.

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Great debate: medical treatment of heart failure with reduced ejection fraction will rely on four foundational drugs.

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The surgical collateralization theory: has the beautiful hypothesis been killed by the ugly facts?

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Beyond single measurement: additional considerations for high-sensitivity C-reactive protein in cardiovascular risk prediction.

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Related Experiment Video

Updated: Jul 25, 2025

A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position
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Paediatric aortic valve replacement: a meta-analysis and microsimulation study.

Maximiliaan L Notenboom1, Art Schuermans2,3,4, Jonathan R G Etnel1

  • 1Department of Cardiothoracic Surgery, Erasmus University Medical Centre, Erasmus MC, Doctor Molewaterplein 40, 3015 GD, Rotterdam, Zuid-Holland, The Netherlands.

European Heart Journal
|June 27, 2023
PubMed
Summary
This summary is machine-generated.

Paediatric aortic valve replacement (AVR) outcomes are suboptimal, with higher mortality in younger children. The Ross procedure offers a survival benefit over mechanical AVR (mAVR), but careful consideration of valve substitutes is crucial.

Keywords:
Aortic valveAortic valve replacementCongenital heart diseaseMicrosimulation

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Area of Science:

  • Cardiovascular Surgery
  • Pediatric Cardiology
  • Biomedical Engineering

Background:

  • Paediatric aortic valve replacement (AVR) decision-making requires comprehensive outcome data.
  • Current outcomes for paediatric AVR are suboptimal, particularly for younger patients.

Approach:

  • A systematic review of 68 studies (5259 patients) published between 1990-2021 was conducted.
  • Data on early/late event rates and time-to-event for Ross, mechanical AVR (mAVR), homograft (hAVR), and bioprosthetic AVR were pooled.
  • Microsimulation modeling was used to estimate age-specific outcomes for different valve substitutes.

Key Points:

  • Pooled early mortality: Ross 3.7%, mAVR 7.0%, hAVR 10.6%.
  • Pooled late mortality rates/year: Ross 0.5%, mAVR 1.0%, hAVR 1.4%.
  • Microsimulation: 20-year reintervention risk was 42.0% for Ross vs. 17.8% for mAVR.

Conclusions:

  • The Ross procedure demonstrates a survival benefit compared to mAVR in paediatric patients.
  • All valve substitutes present considerable reintervention hazards.
  • Careful weighing of pros and cons of each valve substitute is essential for paediatric AVR selection.