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Related Experiment Video

Updated: Jul 25, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

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Nanozyme for tumor therapy: Surface modification matters.

Guoheng Tang1,2, Jiuyang He1, Juewen Liu3

  • 1CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics Chinese Academy of Sciences Beijing 100101 P. R. China.

Exploration (Beijing, China)
|June 27, 2023
PubMed
Summary
This summary is machine-generated.

Surface modification of iron oxide nanozymes is crucial for effective tumor catalytic therapy. Tailoring their surface properties enhances reactive oxygen species generation and improves therapeutic outcomes against cancer.

Keywords:
Fe3O4 nanozymescytotoxicityperoxidase‐like activitysurface modificationtumor catalytic therapy

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Catalysis

Background:

  • Nanozymes offer advantages over natural enzymes for biomedical applications, including enhanced stability and ease of production.
  • Peroxidase-like activity of nanozymes is key for tumor catalytic therapy via reactive oxygen species (ROS) generation.
  • Iron oxide (Fe3O4) nanozymes, early examples with peroxidase-like activity, show promise for tumor therapy but yield inconsistent results.

Purpose of the Study:

  • To review the catalytic mechanisms of Fe3O4 nanozymes in tumor therapy.
  • To discuss the impact of surface modification on Fe3O4 nanozyme performance.
  • To provide an outlook on improving nanozyme-based antitumor activity.

Main Methods:

  • Literature review of Fe3O4 nanozymes in tumor catalytic therapy.
  • Analysis of factors influencing nanozyme peroxidase-like activity.
  • Evaluation of surface modification effects on biodistribution and intracellular fate.

Main Results:

  • Inconsistent cytotoxicity and ROS scavenging observed with Fe3O4 nanozymes.
  • Surface modification significantly impacts Fe3O4 nanozyme peroxidase activity.
  • Surface properties influence nanozyme biodistribution and cellular interactions, affecting therapeutic efficacy.

Conclusions:

  • Surface modification is critical for optimizing Fe3O4 nanozyme therapeutic effects in cancer.
  • Understanding surface-structure-activity relationships is essential for nanozyme design.
  • Targeted surface engineering can enhance nanozyme-based tumor catalytic therapy.