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Updated: Jul 25, 2025
Construction of a Wireless-Enabled Endoscopically Implantable Sensor for pH Monitoring with Zero-Bias Schottky Diode-based Receiver
Published on: August 27, 2021
Aiding gastrointestinal diagnostic laboratory by designing a device for the non invasive detection of peptic ulcer
Mehwish Faiz1, Maheen Murad1, Rabia Khalid1
1Department of Biomedical Engineering, Ziauddin University, Faculty of Engineering, Science, Technology and Management (ZUFESTM), Karachi, Sindh, Pakistan.
Insights
This study introduces a non-invasive device to detect peptic ulcers by monitoring vital signs and saliva pH, aiding in early Helicobacter pylori detection. This method offers a painless alternative to traditional diagnostic procedures.
Area of Science:
- Gastroenterology
- Biomedical Engineering
- Medical Diagnostics
Background:
- Peptic ulcer disease (PUD) is a significant gastrointestinal issue affecting the stomach and duodenum, often linked to Helicobacter pylori (H. pylori) infection.
- Current diagnostic methods for PUD are invasive, painful, and not universally accessible.
- Identifying H. pylori non-invasively is crucial for timely PUD management.
Purpose of the Study:
- To develop and validate a non-invasive device for detecting peptic ulcers.
- To identify H. pylori presence by monitoring key physiological parameters.
- To provide a feasible and accessible diagnostic tool for peptic ulcer disease.
Main Methods:
- Monitoring respiration rate, heart rate, ECG, saliva pH, and body temperature.
- Acquiring biosignals as analog input, converting to digital using MCP3008.
- Processing digital inputs with Raspberry Pi 3 for analysis and output display.
Main Results:
- Physicochemical parameters like heart rate, temperature, and respiratory rate were observed to elevate.
- Saliva pH decreased towards the acidic side, and disturbances in the ECG's QRS complex were noted.
- The device successfully compared obtained parameter values against standard values to determine the presence of peptic ulcers.
Conclusions:
- The developed non-invasive device effectively identifies peptic ulcers by analyzing physiological changes.
- Monitoring respiration rate, heart rate, ECG, saliva pH, and temperature offers a reliable method for H. pylori detection.
- This technology presents a promising, non-invasive alternative for diagnosing peptic ulcer disease.
Abstract:
Peptic ulcer (PU) has been recognized as an utmost gastrointestinal problem that affects the lining of the stomach and duodenum, specifically triggering soreness. It is a life-threatening condition, while roots of the infection are not identified yet. There are various risk factors for the cause of peptic ulcer disease, but the most significant is "Helicobacter pylori" (H. pylori). The detection of this disease involves different invasive procedures which are painful and not feasible for everyone. The aim of this device is to identify the peptic ulcer non-invasively by unmasking the presence of H. Pylori bacterium by monitoring crucial parameters of the disease which include respiration rate, heart rate, ECG, pH of Saliva, and temperature. Multiple investigations related to PU authenticate the alteration in these physicochemical aspects of the body. The increase in the level of stomach acid in PU is responsible for belching and bloating. Heart rate, temperature, and respiratory rate are also elevated during peptic ulcers while the pH of Saliva is decreased toward the acidic side. The disturbance in the QRS complex of the ECG wave is also observed. These biosignals are examined as analog input from the body, sent into MCP3008, and converted into digital input signals. Then these digital inputs are directed toward Raspberry pi 3 which processes, received inputs, and shows output on the LCD. The values of parameters obtained are then compared with standard values and a conclusion is made that whether a patient has a peptic ulcer or not.
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