Physical Exercise Decreases Endoplasmic Reticulum Stress in Central and Peripheral Tissues of Rodents: A Systematic...

Area of Science:

• Cellular Biology
• Physiology
• Exercise Science

Background:

• Endoplasmic reticulum (ER) stress is implicated in chronic disease development.
• Physical exercise (PE) shows promise in preventing and managing chronic diseases.

Purpose of the Study:

• To systematically review the impact of physical exercise protocols on ER stress markers.
• To investigate effects in central and peripheral tissues of rodents.

Main Methods:

• Systematic review of rodent studies using PubMed, Scopus, Science Direct, and SciELO.
• Eligibility criteria based on PICOS framework (Population, Intervention, Control, Outcome, Studies).
• Quality assessment using SYRCLE's risk of bias tool.

Main Results:

• 14 eligible studies were included after screening 2,490 articles.
• Physical exercise protocols demonstrated reduced ER stress markers in rodent cardiac, brain, and skeletal muscle tissues.
• PE effectively mitigates cellular stress in these tissues.

Conclusions:

• Physical exercise can decrease endoplasmic reticulum stress in rodents.
• Further research into optimal PE frequency, duration, and intensity is needed.
• PE offers a potential strategy for counteracting ER stress and associated chronic conditions.