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Updated: Jul 25, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
Neurologic Complications of Cancer Immunotherapy
Aseel N Alsalem1, Leslie A Scarffe1, Hannah R Briemberg1
1Division of Neurology, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
Abstract:
Immunotherapy has revolutionized cancer treatment over the past decade. As it is increasingly introduced into routine clinical practice, immune-related complications have become more frequent. Accurate diagnosis and treatment are essential, with the goal of reduced patient morbidity. This review aims to discuss the various clinical manifestations, diagnosis, treatments, and prognosis of neurologic complications associated with the use of immune checkpoint inhibitors, adoptive T-cell therapies, and T-cell redirecting therapies. We also outline a suggested clinical approach related to the clinical use of these agents.
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