Antibody Phage Display Technology for Sensor-Based Virus Detection: Current Status and Future Prospects.

Area of Science:

• Virology
• Bioengineering
• Nanotechnology

Background:

• Viruses are ubiquitous environmental agents causing significant plant, animal, and human diseases.
• The constant mutation and pathogenicity of viruses necessitate rapid and sensitive detection methods.
• Recent increases in viral disease incidence, like SARS-CoV-2, highlight the limitations of existing diagnostic tools.

Purpose of the Study:

• To review current virus detection methods and their limitations.
• To explore the potential of phage display technology antibodies for enhanced virus detection.
• To assess the application of these engineered antibodies in sensor-based diagnostic systems.

Main Methods:

• Analysis of existing literature on virus detection techniques.
• Examination of phage display technology for antibody generation.
• Evaluation of sensor-based detection principles utilizing bio-engineered macromolecules.

Main Results:

• Phage display technology enables the production of specific, high-affinity antibodies.
• These antibodies can function as sensitive recognition elements in biosensors.
• Sensor-based detection offers a pathway to overcome limitations of conventional diagnostic methods.

Conclusions:

• Phage display antibodies represent a powerful tool for developing next-generation virus detection systems.
• The application of these engineered antibodies in sensors promises improved sensitivity and speed for diagnostics.
• This approach holds significant potential for monitoring and managing viral diseases effectively.