Conceptualization and Investigation of Multicomponent Polymer Networks as Prospective Corticosteroid Carriers

Area of Science:

• Polymer Chemistry
• Materials Science
• Dermatology

Background:

• Dexamethasone (DXM) is a potent glucocorticoid with anti-inflammatory properties.
• Systemic DXM administration causes adverse effects, necessitating alternative delivery methods.
• Dermal application of dexamethasone sodium phosphate (DSP) requires effective drug delivery platforms.

Purpose of the Study:

• To develop and characterize multicomponent polymer networks for dermal delivery of dexamethasone sodium phosphate (DSP).
• To evaluate the drug loading and in vitro release capabilities of these novel polymer networks.

Main Methods:

• Synthesis of copolymer networks (CPN) and interpenetrating polymer networks (IPN) using redox polymerization and crosslinking.
• Characterization via FTIR, TGA, and swelling kinetics studies in various solvents and DSP solutions.
• In vitro drug release studies in buffer solution (pH 7.4) at 37 °C.

Main Results:

• CPN and IPN exhibited high swelling degrees (up to 1800% and 1200%) in aqueous media within 24 hours.
• IPN demonstrated temperature-responsive swelling, with decreased swelling at higher temperatures.
• Drug loading capacity was controllable by DSP solution concentration.
• Successful in vitro release of DSP was observed, confirming platform feasibility.

Conclusions:

• Developed multicomponent hydrophilic polymer networks are effective platforms for potential dermal application of DSP.
• These networks offer controlled drug loading and release profiles suitable for topical therapies.
• The study highlights a promising strategy to enhance therapeutic efficacy while mitigating systemic side effects of dexamethasone.