Related Experiment Video
Updated: Jul 25, 2025
06:45
Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
Published on: May 2, 2025
469
Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds
Maria Rosaria Sellitto1, Chiara Amante1, Rita Patrizia Aquino1
1Department of Pharmacy, University of Salerno, 84084 Fisciano, SA, Italy.
Gels (Basel, Switzerland)
|June 27, 2023
Summary
Researchers developed novel polysaccharide-based aerogel capsules for wound healing drug delivery. These alginate capsules efficiently absorb wound fluid and provide sustained release of ketoprofen lysinate for up to 72 hours.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Biomedical Engineering
Background:
- Polysaccharide-based aerogels are increasingly explored for pharmaceutical applications.
- Drug carriers for wound healing require efficient fluid absorption and controlled drug release.
Purpose of the Study:
- To produce and characterize drug-loaded aerogel capsules using prilling and supercritical extraction.
- To evaluate the potential of these aerogels as carriers for ketoprofen lysinate in wound healing.
Main Methods:
- Inverse gelation via prilling in a coaxial configuration to form core-shell particles.
- Supercritical CO2 drying to create hollow alginate aerogel capsules with tunable thin layers.
- Characterization of porosity, surface area, and textural properties.
Main Results:
- Alginate aerogel capsules exhibited high porosity (up to 95.3%) and surface area (417.0 m²/g).
- The hollow particles rapidly absorbed wound fluid (<30 s) and formed a conformable hydrogel.
- Prolonged drug release of ketoprofen lysinate was achieved for up to 72 hours.
Conclusions:
- The developed alginate aerogel capsules are promising for wound healing applications.
- Their unique structure facilitates rapid fluid absorption and sustained drug delivery.
- This technology offers a novel approach to advanced wound care management.
