Pathophysiologic Contributions of Visceral Adiposity to Left Ventricular Diastolic Dysfunction
Reika Nagata1,2, Masaru Obokata1, Miki Matsui2
1Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Gunma, Japan.
Journal of Cardiovascular Development and Disease
|June 27, 2023
Summary
Increased visceral fat, but not subcutaneous fat, is linked to left ventricular diastolic dysfunction (LVDD). This finding suggests visceral adiposity contributes to LVDD pathophysiology.
Area of Science:
- Cardiology
- Metabolic Syndrome
- Medical Imaging
Background:
- Visceral fat releases inflammatory cytokines, potentially contributing to heart failure with preserved ejection fraction (HFpEF).
- Limited data exist on how visceral fat abnormalities impact left ventricular diastolic dysfunction (LVDD).
Purpose of the Study:
- To investigate the relationship between visceral fat quantity and left ventricular diastolic dysfunction (LVDD).
- To explore the role of visceral adiposity in the pathophysiology of LVDD.
Main Methods:
- Studied 77 patients undergoing abdominal surgery (44 with LVDD, 33 controls).
- Assessed visceral and subcutaneous fat areas via abdominal CT scans.
- Measured mRNA levels of inflammatory cytokines in visceral fat samples.
Main Results:
- Patients with LVDD had significantly larger visceral fat areas compared to controls.
- Visceral fat area correlated with BNP levels, LV mass index, and diastolic function parameters (mitral e' velocity, E/e' ratio).
- No significant differences in visceral adipose tissue cytokine mRNA expression were found between groups.
Conclusions:
- Elevated visceral adiposity is associated with left ventricular diastolic dysfunction (LVDD).
- Visceral fat accumulation may play a pathophysiological role in LVDD.
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