Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple schedule performance changes during carbon monoxide exposure.

J Schrot, J R Thomas

    Neurobehavioral Toxicology and Teratology
    |May 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Snake Bites-Treated by Brandy.

    The North-Western medical and surgical journal·2023
    Same author

    Temperature surpasses the effects of velocity and turbulence on swimming performance of two invasive non-native fish species.

    Royal Society open science·2021
    Same author

    Development of a core outcome set for cutaneous squamous cell carcinoma trials: identification of core domains and outcomes.

    The British journal of dermatology·2020
    Same author

    Leaf consumption by insects in three Eucalyptus forest types in Southeastern Australia and their role in short-term nutrient cycling.

    Oecologia·2017
    Same author

    Effects of nitrogen concentrations of Eucalyptus blakelyi foliage on the fecundity of Paropsis atomaria (Coleoptera: Chrysomelidae).

    Oecologia·2017
    Same author

    Effects of food quality, particularly nitrogen concentrations, of Eucalyptus blakelyi foliage on the growth of Paropsis atomaria larvae (Coleoptera: Chrysomelidae).

    Oecologia·2017

    Carbon monoxide (CO) exposure at high concentrations significantly reduced response rates in rats. Behavioral effects included abrupt cessation of responding, though response patterning remained intact.

    Area of Science:

    • Neuroscience
    • Behavioral Pharmacology
    • Toxicology

    Background:

    • Carbon monoxide (CO) is a toxic gas known to affect oxygen transport in the blood.
    • Understanding the behavioral consequences of CO exposure is crucial for public health and safety.

    Purpose of the Study:

    • To investigate the behavioral effects of varying carbon monoxide concentrations in rats.
    • To determine the threshold for CO-induced behavioral changes using a complex operant schedule.

    Main Methods:

    • Rats were trained on a multiple fixed-ratio 30 differential reinforcement of low rate 18 (MULT FR 30 DRL 18) schedule.
    • Animals were exposed to carbon monoxide (CO) at concentrations from 250 to 850 parts-per-million (PPM) for 30-minute periods.
    • Behavioral responses and carboxyhemoglobin levels were monitored during exposure.

    Related Experiment Videos

    Main Results:

    • Carboxyhemoglobin levels equilibrated within 60 minutes of CO exposure.
    • CO concentrations of 650 PPM and higher significantly reduced overall response rates.
    • The primary behavioral effect was the abrupt cessation of responding, not a change in response patterning or DRL accuracy.

    Conclusions:

    • Carbon monoxide exposure at concentrations of 650 PPM or higher impairs operant behavior in rats.
    • The observed behavioral deficits are characterized by response suppression rather than disruption of response patterning or timing accuracy.