Subclinical Reactive Hypoglycemia with Low Glucose Effectiveness-Why We Cannot Stop Snacking despite Gaining Weight
1Department of Endocrinology and Diabetes, Toyooka Public Hospital, 1094, Tobera, Toyooka 668-8501, Hyogo, Japan.
Metabolites
|June 27, 2023
Summary
Subclinical reactive hypoglycemia (SRH) may drive frequent snacking in obese individuals, creating a cycle. Improving glucose effectiveness (Sg) could help manage snacking and weight.
Area of Science:
- Metabolism and Endocrinology
- Nutritional Science
- Obesity Research
Background:
- Modern lifestyles contribute to global obesity, often involving frequent snacking.
- Subclinical reactive hypoglycemia (SRH) is observed in obese men without diabetes, characterized by post-glucose load hypoglycemia without symptoms.
- SRH is associated with increased snacking frequency, potentially forming a "snacking begets snacking" cycle.
Purpose of the Study:
- To review the potential role of subclinical reactive hypoglycemia (SRH) in the snacking habits of individuals with obesity or overweight.
- To explore the relationship between SRH, snacking, obesity, and glucose effectiveness (Sg).
Main Methods:
- Review of existing data on continuous glucose monitoring in obese/overweight men without diabetes.
- Analysis of the association between SRH, snacking habits, obesity, dysglycemia, and glucose effectiveness (Sg).
Main Results:
- Half of obese/overweight men without diabetes exhibited subclinical reactive hypoglycemia (SRH) after an oral glucose load.
- Lower glucose effectiveness (Sg) was linked to SRH, snacking habits, obesity, and dysglycemia.
- Higher Sg was associated with SRH, but not directly with snacking or obesity.
Conclusions:
- Subclinical reactive hypoglycemia (SRH) may act as a mediator linking snacking habits to obesity, particularly in individuals with low glucose effectiveness (Sg).
- Enhancing glucose effectiveness (Sg) could be a strategy to manage snacking behaviors and control body weight in this population.
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