Related Experiment Video
Updated: Jul 25, 2025

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Should direct oral anticoagulants be used to treat protein C or S deficiency?
Kiya K Bennett1, Nicholas C Schwier
1Kiya K. Bennett is an assistant professor in the Department of Pharmacy: Clinical and Administrative Sciences in the University of Oklahoma Health Sciences Center's College of Pharmacy in Oklahoma City, and a clinical pharmacy specialist in internal medicine at the University of Oklahoma Medical Center. At the time this article was written, Nicholas C. Schwier was an associate professor in the Department of Pharmacy: Clinical and Administrative Sciences at the University of Oklahoma and a clinical pharmacy specialist in cardiology at the University of Oklahoma Medical Center. He now is assistant dean of experiential education and a clinical associate professor in the School of Pharmacy and Pharmaceutical Sciences at Binghamton University in Johnson City, N.Y. Dr. Schwier discloses that he has received honoraria from and serves on the speaker's bureau for Kiniksa Pharmaceuticals. The authors have disclosed no other potential conflicts of interest, financial or otherwise.
Abstract:
Few studies have evaluated the use of direct oral anticoagulants (DOACs) in patients with major thrombophilias, such as protein C or S deficiency. The data related to use of DOACs in treating protein C or S deficiency are heterogeneous, consisting of various DOACs, inconsistent ranges of dosing, dissimilar patient demographics, and inconsistent clinical endpoints. Vitamin K antagonists and low-molecular-weight heparins are preferred until more robust data are available about using DOACs in patients with protein C or S deficiency.
Related Concept Videos
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Venous Thrombosis III: Interprofessional Care
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...

