Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellular immunity in asbestosis.

A Lange, R Smolik, W Chmielarczyk

    Archivum Immunologiae Et Therapiae Experimentalis
    |January 1, 1978
    PubMed
    Summary

    Asbestosis is linked to weakened immune responses, including skin reactions and lymphocyte function. This study highlights immune system impairments in asbestos-exposed individuals, particularly those with antinuclear antibodies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of different irrigation water temperatures on the vegetative development of mung beans (Vigna radiata L.).

    Brazilian journal of biology = Revista brasleira de biologia·2025
    Same author

    Advancing technical understanding of the double-seeded gill cell culture system for drug uptake studies in fish.

    Environmental toxicology and chemistry·2025
    Same author

    A blinded randomised split-body clinical trial evaluating the effect of fluorescent light energy on antimicrobial management of canine interdigital furunculosis.

    Veterinary dermatology·2025
    Same author

    Old breeds, new solutions? Effects of two different traditional sire breeds on skin lesions, tail lesions, tail losses, performance and behaviour of rearing pigs.

    Animal : an international journal of animal bioscience·2023
    Same author

    Formation of Re-Aggregated Neonatal Porcine Islet Clusters Improves <i>In Vitro</i> Function and Transplantation Outcome.

    Transplant international : official journal of the European Society for Organ Transplantation·2023
    Same author

    The -2549 -2567 del18 Polymorphism in VEGF and Irreversible Bronchoconstriction in Asthmatics.

    Journal of investigational allergology & clinical immunology·2018

    Area of Science:

    • Immunology
    • Occupational Health
    • Pulmonology

    Background:

    • Asbestos exposure is a known cause of lung disease, including asbestosis.
    • The impact of asbestosis on the immune system is not fully understood.
    • Cellular immune responses may be altered in individuals with asbestos-related conditions.

    Purpose of the Study:

    • To investigate the relationship between asbestosis and immune system responsiveness.
    • To examine the prevalence of antinuclear antibodies (ANA) in asbestos workers.
    • To assess lymphocyte profiles and function in patients with asbestosis.

    Main Methods:

    • Skin reactions to tuberculin and SK-SD were assessed.
    • Antinuclear antibody (ANA) incidence was determined.
    • Peripheral blood lymphocyte subsets (E-RFC) were analyzed.
    • Macrophage migration inhibition factor (MIF) tests were performed.
    • Lymphocyte transformation assays using PHA and ConA were conducted.

    Main Results:

    • A significant correlation was observed between asbestosis and reduced skin test responsiveness.
    • Higher ANA frequency was noted in asbestos workers lacking cutaneous responses.
    • Asbestosis cases showed abnormal lymphocyte profiles with low E-RFC.
    • Impaired cytokine generation (MIF) was detected in response to stimuli in asbestosis patients.
    • Lymphocyte transformation was impaired, especially at lower doses of PHA and ConA, in asbestosis and ANA-positive asbestos workers.

    Conclusions:

    • Asbestosis is associated with significant impairments in cellular immune responses.
    • ANA may be a marker for altered immune function in asbestos-exposed individuals.
    • These findings suggest a compromised immune status in asbestosis, potentially increasing susceptibility to infections.

    Related Experiment Videos